Structure of PDB 7tjk Chain E

Receptor sequence
>7tjkE (length=437) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKYF
NANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPLQ
VEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYIK
LNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTIL
VMSRCGELMEDSCLRKRIIEEDDQFQNVAANFIHLIVQAFHSYTGNDIFA
LNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLLSIISKYL
LIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKKEVNPRYLQPSLF
AIERLLAIFQAIFPIALREESLMKANIEVFQNLSELHTLKLIATTMNKNI
DYLSPKVRWKVNVPWEIIKEISESVHFNISDYFSDIH
3D structure
PDB7tjk A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
ChainE
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E R360 R366 N440 R329 R335 N399
BS02 dna E Y345 R360 Y363 R365 R366 T436 Y314 R329 Y332 R334 R335 T395
BS03 ATP E S39 G40 T41 G42 K43 T44 Y45 Y192 I200 M203 F256 S38 G39 T40 G41 K42 T43 Y44 Y191 I199 M202 F249
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex
GO:0035361 Cul8-RING ubiquitin ligase complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:7tjk, PDBe:7tjk, PDBj:7tjk
PDBsum7tjk
PubMed35217664
UniProtP50874|ORC5_YEAST Origin recognition complex subunit 5 (Gene Name=ORC5)

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