Structure of PDB 7tjj Chain E

Receptor sequence
>7tjjE (length=438) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NVTTPEVAFREYQTNCLASYISADPDITPSNLILQGYSGTGKTYTLKKYF
NANPNLHAVWLEPVELVSWKPLLQAIARTVQYKLKTLYPNIPTTDYDPLQ
VEEPFLLVKTLHNIFVQYESLQEKTCLFLILDGFDSLQDLDAALFNKYIK
LNELLPKDSKINIKFIYTMLETSFLQRYSTHCIPTVMFPRYNVDEVSTIL
VMSRCGELMEDSCLRKRIIEEDDQFQNVAANFIHLIVQAFHSYTGNDIFA
LNDLIDFKWPKYVSRITKENIFEPLALYKSAIKLFLSTDDNLDLSIISKY
LLIASYICSYLEPRYDASIFSRKTRIIQGRAAYGRRKKKEVNPRYLQPSL
FAIERLLAIFQAIFPIALREESLMKANIEVFQNLSELHTLKLIATTMNKN
IDYLSPKVRWKVNVPWEIIKEISESVHFNISDYFSDIH
3D structure
PDB7tjj A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6.
ChainE
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E Q358 R360 Y363 R366 N440 Q328 R330 Y333 R336 N400
BS02 dna E R344 Y345 R360 Y363 G364 R365 R366 K367 T436 K447 R314 Y315 R330 Y333 G334 R335 R336 K337 T396 K407
BS03 ATP E S39 G40 T41 G42 K43 T44 Y45 I200 F256 S38 G39 T40 G41 K42 T43 Y44 I199 F249
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
GO:0030466 silent mating-type cassette heterochromatin formation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005656 nuclear pre-replicative complex
GO:0005664 nuclear origin of replication recognition complex
GO:0031261 DNA replication preinitiation complex
GO:0035361 Cul8-RING ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tjj, PDBe:7tjj, PDBj:7tjj
PDBsum7tjj
PubMed35217664
UniProtP50874|ORC5_YEAST Origin recognition complex subunit 5 (Gene Name=ORC5)

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