Structure of PDB 7tfh Chain E

Receptor sequence
>7tfhE (length=341) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MSLWVDKYRPKSLNALSHNEELTNFLKSLSDQPRDLPHLLLYGPNGTGKK
TRCMALLESIFGPGVYRLKIDVRQFVTASNRKLELNVVSSPYHLEITPSD
MGNNDRIVIQELLKEVAQMHRYKCVIINEANSLTKDAQAALRRTMEKYSK
NIRLIMVCDSMSPIIAPIKSRCLLIRCPAPSDSEISTILSDVVTNERIQL
ETKDILKRIAQASNGNLRVSLLMLESMALNNELALKSSSPIIKPDWIIVI
HKLTRKIVKERSVNSLIECRAVLYDLLAHCIPANIILKELTFSLLDVETL
NTTNKSSIIEYSSVFDERLSLGNKAIFHLEGFIAKVMCCLD
3D structure
PDB7tfh Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
ChainE
Resolution3.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E V5 P10 L16 H18 G46 T47 G48 K49 K50 I201 L230 R231 V5 P10 L16 H18 G46 T47 G48 K49 K50 I188 L217 R218
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0007062 sister chromatid cohesion
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tfh, PDBe:7tfh, PDBj:7tfh
PDBsum7tfh
PubMed35829698
UniProtP38251|RFC5_YEAST Replication factor C subunit 5 (Gene Name=RFC5)

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