Structure of PDB 7tbh Chain E

Receptor sequence
>7tbhE (length=243) Species: 9606,10090 [Search protein sequence]
TQDLRSHLVHKLVQAIFPCPDPCALKDRRMENLVAYAKKVEGDMYESANS
RDEYYHLLAEKIYKIQKELEEKSQVRQNYHQDAEAAINRQINLELYASYV
YLSMSCYFDRDDVALKNFAKYFLHQSHEEREHAEKLMKLQNQRGGRIFLQ
DIKKPDRDDWCSGLNAMESALHLEKSVNQSLLELHKLATDKNDPHLCDFI
ETYYLSEQVKSIKELGDHVTNLRKMGAPCAGMAEYLFDKHTLG
3D structure
PDB7tbh Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia.
ChainE
Resolution2.3 Å
3D
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Enzymatic activity
Enzyme Commision number 1.16.3.1: ferroxidase.
2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E Y63 Y71 K75 Q89 F156 Q158 Y55 Y63 K67 Q81 F148 Q150
Gene Ontology
Molecular Function
GO:0003712 transcription coregulator activity
GO:0004322 ferroxidase activity
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140315 iron ion sequestering activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006955 immune response
GO:0008285 negative regulation of cell population proliferation
GO:0048147 negative regulation of fibroblast proliferation
GO:0110076 negative regulation of ferroptosis
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005776 autophagosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0044754 autolysosome
GO:0071682 endocytic vesicle lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tbh, PDBe:7tbh, PDBj:7tbh
PDBsum7tbh
PubMed35233453
UniProtP09528|FRIH_MOUSE Ferritin heavy chain (Gene Name=Fth1);
Q92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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