Structure of PDB 7s60 Chain E

Receptor sequence
>7s60E (length=1395) Species: 9606 (Homo sapiens) [Search protein sequence]
PLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGW
GSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTES
HHLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKT
IKFVKFLDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFDLG
VRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQ
RLCEAFDAQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGI
VDHLGKLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETG
INLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFL
CPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQA
QRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLR
AFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFH
ILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIRDNCCVQIMGGYFTW
TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVF
WSRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDI
LPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHL
SDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTL
KDFQRSECQLFEHWKTLMNRQDQELEKPWRACAKYLSSAGILLLSLLVFS
QLLKHMVLVAIDYWLAKWTDSADQTVYAMVFTVLCSLGIVLCLVTSVTVE
WTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIP
STLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASR
DLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIA
SLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTY
ALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPK
NWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSS
FSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIR
FNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQR
QLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIA
HRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVRADK
3D structure
PDB7s60 Molecular structure of an open human K ATP channel.
ChainE
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E Y1354 T1381 G1382 S1383 G1384 K1385 S1386 S1387 Y1167 T1194 G1195 S1196 G1197 K1198 S1199 S1200
BS02 MG E S721 Q775 S632 Q661
BS03 ATP E S409 W689 T696 G717 G719 K720 S721 S722 Q775 E1480 N1481 S1483 G1485 S374 W600 T607 G628 G630 K631 S632 S633 Q661 E1293 N1294 S1296 G1298
Gene Ontology
Molecular Function
GO:0005267 potassium channel activity
GO:0005524 ATP binding
GO:0008281 sulfonylurea receptor activity
GO:0015272 ATP-activated inward rectifier potassium channel activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0043531 ADP binding
GO:0044325 transmembrane transporter binding
GO:0140359 ABC-type transporter activity
Biological Process
GO:0001508 action potential
GO:0001678 intracellular glucose homeostasis
GO:0006813 potassium ion transport
GO:0007565 female pregnancy
GO:0007613 memory
GO:0008542 visual learning
GO:0009268 response to pH
GO:0009410 response to xenobiotic stimulus
GO:0010043 response to zinc ion
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0016525 negative regulation of angiogenesis
GO:0031669 cellular response to nutrient levels
GO:0032496 response to lipopolysaccharide
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032868 response to insulin
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0043268 positive regulation of potassium ion transport
GO:0046676 negative regulation of insulin secretion
GO:0050768 negative regulation of neurogenesis
GO:0050905 neuromuscular process
GO:0055085 transmembrane transport
GO:0060253 negative regulation of glial cell proliferation
GO:0061535 glutamate secretion, neurotransmission
GO:0061855 negative regulation of neuroblast migration
GO:0071805 potassium ion transmembrane transport
GO:0098662 inorganic cation transmembrane transport
GO:1900721 positive regulation of uterine smooth muscle relaxation
GO:1905075 positive regulation of tight junction disassembly
GO:1905604 negative regulation of blood-brain barrier permeability
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0008282 inward rectifying potassium channel
GO:0016020 membrane
GO:0030672 synaptic vesicle membrane
GO:0031004 potassium ion-transporting ATPase complex
GO:0032991 protein-containing complex
GO:0042383 sarcolemma
GO:0042734 presynaptic membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7s60, PDBe:7s60, PDBj:7s60
PDBsum7s60
PubMed34815345
UniProtQ09428|ABCC8_HUMAN ATP-binding cassette sub-family C member 8 (Gene Name=ABCC8)

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