Structure of PDB 7rgl Chain E

Receptor sequence
>7rglE (length=416) Species: 9606 (Homo sapiens) [Search protein sequence]
MADYLISGGTGYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVD
LTSALTRKITLKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQ
ANEVRKVKKFEQGFITDPVAPAGVTLKEANKLPILVAIIARTDLKKNRDY
PLASKDSQKQLLCGAAVGTREDDKYRLDLLTQAGVDVIVLDSSQGNSVYQ
IAMVHYIKQKYPHLQVIGGNVVTAAQAKNLIDAGVDGLRVGMGCGSICIT
QEVMACGRPQGTAVYKVAEYARRFGVPIIADGGIQTVGHVVKALALGAST
VMMGSLLAATTEAPGEYFFSDGVRLKKYRGMGSLDAMEVKIAQGVSGSIQ
DKGSIQKFVPYLIAGIQHGCQDIGARSLSVLRSMMYSGELKFEKRTMSAQ
IEGGVHGLHSYTFLPF
3D structure
PDB7rgl IMPDH1 retinal variants control filament architecture to tune allosteric regulation.
ChainE
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP E S68 M70 R322 G328 S329 I330 C331 D364 G387 S388 Y411 G413 M414 G415 Q441 S68 M70 R239 G245 S246 I247 C248 D281 G304 S305 Y328 G330 M331 G332 Q343
BS02 NAD E T252 R253 D274 S276 Y282 M325 C331 M414 T169 R170 D191 S193 Y199 M242 C248 M331
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:1904813 ficolin-1-rich granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rgl, PDBe:7rgl, PDBj:7rgl
PDBsum7rgl
PubMed35013599
UniProtP20839|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

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