Structure of PDB 7rfg Chain E

Receptor sequence

>7rfgE (length=491) Species: 9606 (Homo sapiens) [Search protein sequence]

GYVPEDGLTAQQLFASADGLTYNDFLILPGFIDFIADEVDLTSALTRKIT
LKTPLISSPMDTVTEADMAIAMALMGGIGFIHHNCTPEFQANEVRKVKKF
EQGFITDPVVLSPSHTVGDVLEAKMRHGFSGIPITETGTMGSKLVGIVTS
RDIDFLAEKDHTTLLSEVMTPRIELVVAPAGVTLKEANEILQRSKKGKLP
IVNDCDELVAIIARTDLKKNRDYPLASKDSQKQLLCGAAVGTREDDKYRL
DLLTQAGVDVIVLDSSQGNSVYQIAMVHYIKQKYPHLQVIGGNVVTAAQA
KNLIDAGVDGLRVGMGCGSICITQEVMACGRPQGTAVYKVAEYARRFGVP
IIADGGIQTVGHVVKALALGASTVMMGSLLAATTEAPGEYFFSDGVRLKK
YRGMGSLDAMEKSVKIAQGVSGSIQDKGSIQKFVPYLIAGIQHGCQDIGA
RSLSVLRSMMYSGELKFEKRTMSAQIEGGVHGLHSYEKRLY

3D structure

PDB

7rfg IMPDH1 retinal variants control filament architecture to tune allosteric regulation.

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.1.205: IMP dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	GTP	E	E111 Q112 L194 N198 L227 N230 K238 K242	E101 Q102 L184 N188 L217 N220 K228 K232
BS02	GTP	E	K109 Q112 P118 F139 S140 G141 S160 K208 T225 D226	K99 Q102 P108 F129 S130 G131 S150 K198 T215 D216
BS03	ATP	E	T159 R161 D162 T180 L185 V186 K206 G207	T149 R151 D152 T170 L175 V176 K196 G197
BS04	IMP	E	S68 M70 G328 S329 C331 D364 G365 G366 G387 S388 Y411 G413 M414 G415 Q441 G442	S58 M60 G318 S319 C321 D354 G355 G356 G377 S378 Y401 G403 M404 G405 Q418 G419

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006183	GTP biosynthetic process

	Cellular Component
GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0034774	secretory granule lumen
GO:0035578	azurophil granule lumen
GO:1904813	ficolin-1-rich granule lumen

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7rfg, PDBe:7rfg, PDBj:7rfg
PDBsum	7rfg
PubMed	35013599
UniProt	P20839\|IMDH1_HUMAN Inosine-5'-monophosphate dehydrogenase 1 (Gene Name=IMPDH1)

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