Structure of PDB 7rec Chain E

Receptor sequence
>7recE (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]
MVRKQEIIKVNQQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLD
FHRFYFENLKPVHNTMLNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQ
SEETRVWHRRDGKWQHVHMHRSGAP
3D structure
PDB7rec GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain.
ChainE
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.11.17: calcium/calmodulin-dependent protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7ZV E I361 Y369 E381 H395 Y398 R433 R453 M467 R469 I18 Y26 E38 H52 Y55 R85 R105 M119 R121
Gene Ontology
Molecular Function
GO:0004683 calcium/calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7rec, PDBe:7rec, PDBj:7rec
PDBsum7rec
PubMed34330837
UniProtQ9UQM7|KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha (Gene Name=CAMK2A)

[Back to BioLiP]