Structure of PDB 7r6v Chain E

Receptor sequence
>7r6vE (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
AVLEQFGFPLTGTEARCYTNHALSYDQAKRVPRWVLEHISKSKIMGDADR
KHCKFKPDPNIPPTFSAFNEDYVGSGWSRGHMAPAGNNKFSSKAMAETFY
LSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVSGPLTLPQTRGDGK
KIVSYQVIGEDNVAVPSHLYKVILARRSSVSTEPLALGAFVVPNEAIGFQ
PQLTEFQVSLQDLEKLSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTL
YLSTRKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYE
3D structure
PDB7r6v Human EXOG possesses strong AP hydrolysis activity
ChainE
Resolution2.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.30.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E R109 S137 R138 H140 G145 K148 F168 N171 S172 N176 L311 R50 S78 R79 H81 G86 K89 F109 N112 S113 N117 L252
BS02 dna E K113 S172 G257 F258 F304 L311 K315 K54 S113 G198 F199 F245 L252 K256
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:7r6v, PDBe:7r6v, PDBj:7r6v
PDBsum7r6v
PubMed
UniProtQ9Y2C4|EXOG_HUMAN Nuclease EXOG, mitochondrial (Gene Name=EXOG)

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