Structure of PDB 7r39 Chain E

Receptor sequence

>7r39E (length=412) Species: 2285 (Sulfolobus acidocaldarius)

RVKDLSLAEQGRKQIEWAELHMPALMEIRKRFNAEKPLDGIRIGAVLHVT
KETAVLVETLKAGGAEIALAGSNPLSTQDDVAAGLAKNGIHVYAWRGETE
KDYYDNIREILKYEPHVIMDDGGDLHAYVHENNLTSKIVGGTEETTTGVI
RLKAMEEEKVLKYPVIAVNNAFTKYLFDNRIGTGQSTIDGILRATNILIA
GKVAVVIGYGWVGRGIASRFKGMGARVIVVESSPFRALEALMDGFDVMTM
NRASEIGDIFVTATGNLNVVSRDHILRMKDGAVLANSGHFNVEIDVKGLK
EISVETREVRQNLEEYKLRNGKRIYLLADGRLVNLVAAEGHPSEVMDLSF
CNQALSVEHLIKNKGKLENKVYNVPIEIDEQVARLKLKALGIEIEELTIE
QKEYIKQWKYGT

3D structure

• PDB: 7r39 Crystal structure of S-adenosyl-L-homocysteine hydrolase from Sulfolobus acidocaldarius in complex with adenosine
• Chain: E
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 3.13.2.1: adenosylhomocysteinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	E	T148 T149 T150 N182 T186 G213 W214 V215 E234 S235 R239 T267 V272 S290 G291 N337 H344	T145 T146 T147 N179 T183 G210 W211 V212 E231 S232 R236 T264 V269 S287 G288 N334 H341
BS02	ADN	E	H51 T53 E55 D124 E147 T148 K177 D181 L335 L338 G343 H344 M349	H48 T50 E52 D121 E144 T145 K174 D178 L332 L335 G340 H341 M346

Gene Ontology

Molecular Function

• GO:0004013 adenosylhomocysteinase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0033353 S-adenosylmethionine cycle
• GO:0071269 L-homocysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7r39, PDBe:7r39, PDBj:7r39
• PDBsum: 7r39
• PubMed: 38548921
• UniProt: Q4JAZ7|SAHH_SULAC Adenosylhomocysteinase (Gene Name=ahcY)