Structure of PDB 7qxw Chain E

Receptor sequence
>7qxwE (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
QYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLD
KSKLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGL
SEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVA
SQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAI
GGRRFSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPA
LLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEAIVKLSDGF
NGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKP
V
3D structure
PDB7qxw Mechanism of 26S proteasome activation by the 19S-interacting protein ZFAND5
ChainE
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E D265 R291 D227 R253
BS02 ADP E P176 G177 T178 G179 K180 T181 L182 I312 H316 G340 A341 P138 G139 T140 G141 K142 T143 L144 I274 H278 G302 A303
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0030674 protein-macromolecule adaptor activity
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0036503 ERAD pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0090261 positive regulation of inclusion body assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0016234 inclusion body
GO:0022624 proteasome accessory complex
GO:0031597 cytosolic proteasome complex
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qxw, PDBe:7qxw, PDBj:7qxw
PDBsum7qxw
PubMed37595557
UniProtP62333|PRS10_HUMAN 26S proteasome regulatory subunit 10B (Gene Name=PSMC6)

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