Structure of PDB 7q43 Chain E

Receptor sequence
>7q43E (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
TKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVT
VEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRH
ATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGS
SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC
GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVC
QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKK
IVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEG
QKITRVACGSSHSVAWTT
3D structure
PDB7q43 Crystal structure of RCC1-Like domain 2 of ubiquitin ligase HERC2 in complex with DXDKDED motif of dedicator of cytokinesis protein 10
ChainE
Resolution2.40002 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.26: HECT-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E D2968 S2978 K2979 K3002 R3161 A3214 K3231 Y3234 R3236 H3286 S3318 S3319 D10 S20 K21 K44 R203 A256 K273 Y276 R278 H328 S360 S361
External links
PDB RCSB:7q43, PDBe:7q43, PDBj:7q43
PDBsum7q43
PubMed
UniProtO95714|HERC2_HUMAN E3 ubiquitin-protein ligase HERC2 (Gene Name=HERC2)

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