Structure of PDB 7pzc Chain E

Receptor sequence
>7pzcE (length=880) Species: 9606 (Homo sapiens) [Search protein sequence]
KKDYRKKYRKYVRSRFQCIEESVSLNKRYTRLRLIKEHRSQSPVSPIKME
LLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYL
FYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE
LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALE
KLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLF
TMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGG
SQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMN
LFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSR
DVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRL
ELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEIN
LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQC
VLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDP
GMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLS
DNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHS
LTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSS
VLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH
CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLS
EMYFNYETKSALETLQEEKPELTVVFEPSW
3D structure
PDB7pzc Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3.
ChainE
Resolution3.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP E G229 I230 G231 K232 T233 I234 F373 Y381 W416 H522 G73 I74 G75 K76 T77 I78 F217 Y225 W260 H366
BS02 8GI E A227 A228 R351 M408 I411 I574 F575 R578 L628 E629 Y632 M661 A71 A72 R195 M252 I255 I418 F419 R422 L472 E473 Y476 M505
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0030674 protein-macromolecule adaptor activity
GO:0035591 signaling adaptor activity
GO:0042802 identical protein binding
GO:0042834 peptidoglycan binding
GO:0043531 ADP binding
GO:0043565 sequence-specific DNA binding
GO:0060090 molecular adaptor activity
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0140297 DNA-binding transcription factor binding
GO:0140299 molecular sensor activity
GO:0140608 cysteine-type endopeptidase activator activity
GO:0140693 molecular condensate scaffold activity
GO:1901981 phosphatidylinositol phosphate binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0002674 negative regulation of acute inflammatory response
GO:0002830 positive regulation of type 2 immune response
GO:0006915 apoptotic process
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007231 osmosensory signaling pathway
GO:0009595 detection of biotic stimulus
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032753 positive regulation of interleukin-4 production
GO:0044546 NLRP3 inflammasome complex assembly
GO:0045087 innate immune response
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051604 protein maturation
GO:0070269 pyroptotic inflammatory response
GO:0071222 cellular response to lipopolysaccharide
GO:0098586 cellular response to virus
GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction
GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
GO:2000553 positive regulation of T-helper 2 cell cytokine production
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0031021 interphase microtubule organizing center
GO:0061702 canonical inflammasome complex
GO:0072559 NLRP3 inflammasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pzc, PDBe:7pzc, PDBj:7pzc
PDBsum7pzc
PubMed35114687
UniProtQ96P20|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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