Structure of PDB 7pmv Chain E

Receptor sequence

>7pmvE (length=1139) Species: 9606 (Homo sapiens)

STARCSLFGSDFVNTFDGSMYSFAGYCSYLLAGGCQKRSFSIIGDFQNGK
RVSLSVYLGEFFDIHLFVNGTVTQGDQRVSMPYASKGLYLETEAGYYKLS
GEAYGFVARIDGSGNFQVLLSDRYFNKTCGLCGNFNIFAEDDFMTQEGTL
TSDPYDFANSWALSSGEQWCERASPPSSSCLWEQCQLLKSTSVFARCHPL
VDPEPFVALCEKTLCECAGGLECACPALLEYARTCAQEGMVLYGWTDHSA
CSPVCPAGMEYRQCVSPCARTCQSLHINEMCQERCVDGCSCPEGQLLDEG
LCVESTECPCVHSGKRYPPGTSLSRDCNTCICRNSQWICSNEECPGECLV
TGQSHFKSFDNRYFTFSGICQYLLARDCQDHSFSIVIETVQCADDRDAVC
TRSVTVRLPGLHNSLVKLKHGAGVAMDGQDVQLPLLKGDLRIQHTVTASV
RLSYGEDLQMDWDGRGRLLVKLSPVYAGKTCGLCGNYNGNQGDDFLTPSG
LAEPRVEDFGNAWKLHGDCQDLQKQHSDPCALNPRMTRFSEEACAVLTSP
TFEACHRAVSPLPYLRNCRYDVCSCSDGRECLCGALASYAAACAGRGVRV
AWREPGRCELNCPKGQVYLQCGTPCNLTCRSLSYPDEECNEACLEGCFCP
PGLYMDERGDCVPKAQCPCYYDGEIFQPEDIFSDHHTMCYCEDGFMHCTR
PPMVKLVCPADNLRAEGLECTKTCQNYDLECMSMGCVSGCLCPPGMVRHE
NRCVALERCPCFHQGKEYAPGETVKIGCNTCVCRDRKWNCTDHVCDATCS
TIGMAHYLTFDGLKYLFPGECQYVLVQDYCGSNPGTFRILVGNKGCSHPS
VKCKKRVTILVEGGEIELFDGEVNVKRPMKDETHFEVVESGRYIILLLGK
ALSVVWDRHLSISVVLKQTYQEKVCGLCGNFDGIQNNDLTSSNLQVEEDP
VDFGNSWKVSSQCADTRKVPLDSSPATCHNNIMKQTMVDSSCRILTSDVF
QDCNKLVDPEPYLDVCIYDTCSCESIGDCACFCDTIAAYAHVCAQHGKVV
TWRTATLCPQSCEERNLRENGYECEWRYNSCAPACQVTCQHPEPLACPVQ
CVEGCHAHCPPGKILDELLQTCVDPEDCPVCEVAGRRFA

3D structure

• PDB: 7pmv Helical self-assembly of a mucin segment suggests an evolutionary origin for von Willebrand factor tubules.
• Chain: E
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	E	D879 N998 F999 D1000 I1002 D1006	D811 N930 F931 D932 I934 D938
BS02	CA	E	D47 N164 N166 F168 D172	D17 N134 N136 F138 D142
BS03	CA	E	D400 N526 N528 N530 D534	D360 N486 N488 N490 D494

External links

• PDB: RCSB:7pmv, PDBe:7pmv, PDBj:7pmv
• PDBsum: 7pmv
• PubMed: 35377815
• UniProt: P04275|VWF_HUMAN von Willebrand factor (Gene Name=VWF)