Structure of PDB 7pe7 Chain E

Receptor sequence
>7pe7E (length=1115) Species: 9606 (Homo sapiens) [Search protein sequence]
NVPLDLTREPSDNLREILQNVARLQGVSNMRKLGHLNNFTKLLCDIGHSE
EKLGFHYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLK
VDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVTNSLIAVGN
DGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRIN
EALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLK
EDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIR
RGLLEVLYDIFRLPLPVVTEEFIEALLSVDPGRFQDSWRLSDGFVAAEAK
TILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRAT
ILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALN
CLKRFHEMKKRGPKPYSLHLDHIIQKAIATHQKRDQILKDTEEALLINLR
DSQVLQHKENLEWNWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKP
SSKLYANLDLDFAKAKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQW
LNASSGMKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQ
CLLNLCSLKNQDHLLKLTVSSLDYSRDGLARVILSKILTAATDACRLYAT
KHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKAN
LHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHR
EYNSKYVDLIEEQLNEALTTYRKPQRPHVYLPIHLYGQLVHHKTGCHLLE
VQNIITELCRNVRTPDLDKWEEIKKLKASLWALGNIGSSNWGLNLLQEEN
VIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHNWDAVRHSR
KHLWPVVPDYIGLALPVDINDIFQVKDIPYFQTKSFHLLRQQMSLTEIMN
TGLQEHTDDNCLYCVCIEILGFQPSNQMCRILLRKEVLRLVINLSSSVST
KCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLPCRRFIQELFQD
VQFLQMHEEAEAVLA
3D structure
PDB7pe7 Regulation of human mTOR complexes by DEPTOR.
ChainE
Resolution3.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E H1515 C1520 C1523 C1651 H1006 C1011 C1014 C1072
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0043022 ribosome binding
GO:0043539 protein serine/threonine kinase activator activity
GO:0060090 molecular adaptor activity
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007010 cytoskeleton organization
GO:0009792 embryo development ending in birth or egg hatching
GO:0010468 regulation of gene expression
GO:0018105 peptidyl-serine phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0030307 positive regulation of cell growth
GO:0030838 positive regulation of actin filament polymerization
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032956 regulation of actin cytoskeleton organization
GO:0038203 TORC2 signaling
GO:0043066 negative regulation of apoptotic process
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:2000114 regulation of establishment of cell polarity
Cellular Component
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0031932 TORC2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pe7, PDBe:7pe7, PDBj:7pe7
PDBsum7pe7
PubMed34519268
UniProtQ6R327|RICTR_HUMAN Rapamycin-insensitive companion of mTOR (Gene Name=RICTOR)

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