Structure of PDB 7oqc Chain E

Receptor sequence
>7oqcE (length=544) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MDKYTALIHDENFSTLTLNVSRYPKSLAYWEKLLNYIVKASAPICKSTEP
QLLKLIRCTYSSMLNEFPYLENYYIDFALLEYKLGNVSMSHKIFQRGLQA
FNQRSLLLWTSYLKFCNNVISHQKQLFKKYETAEEYVGLHFFSGEFWDLY
LEQISSRCTSSKKYWNVLRKILEIPLHSFSKFYALWLQRIDDIMDLKQLS
QLTSKDELLKKLKIDINYSGRKGPYLQDAKKKLKKITKEMYMVVQYQVLE
IYSIFESKIYINYYTSPETLVSSDEIETWIKYLDYTITLQTDSLTHLNFQ
RALLPLAHYDLVWIKYSKWLINSKNDLLGAKNVLLMGLKFSLKKTEIIKL
LYSVICKLNEYVLLRNLLEKIESSYSDNVENVDDFEIFWDYLQFKTFCQN
SLYSSRYSDSQSNGLLNKELFDKVWKRLSCKEKKSGQEILLNNLVQFYSK
DTVEFVEKNIFQKIIEFGWEYYLQNGMFWNCYCRLIYFDTSRSYLDKRQY
IVRKIWPQIDKKFAQSVLPSLTEFCESYFPEEMDTLEEMFTEEP
3D structure
PDB7oqc Structural insights into how Prp5 proofreads the pre-mRNA branch site.
ChainE
Resolution4.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna E Q95 Q123 Q125 K128 C158 M194 D195 L196 G220 R221 K222 G223 Q95 Q123 Q125 K128 C158 M194 D195 L196 G220 R221 K222 G223
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0030627 pre-mRNA 5'-splice site binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7oqc, PDBe:7oqc, PDBj:7oqc
PDBsum7oqc
PubMed34349264
UniProtQ03776|PRP42_YEAST U1 small nuclear ribonucleoprotein component PRP42 (Gene Name=PRP42)

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