Structure of PDB 7nyd Chain E

Receptor sequence
>7nydE (length=484) Species: 9606 (Homo sapiens) [Search protein sequence]
AATPAAVTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWD
QASCSSSTTCVRQAQCGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDC
AIDEDCSQYEPIPGSQKAALGYNILTQEDAQSVYDASYYGGQCETVYNGE
WRELRYDSTCERLYYGDDEKYFRKPYNFLKYHFEALADTGISSEFYDNAN
DLLSKVKKDFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGML
QSLMELPDQYNYGMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESL
GITSGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNRSTITYRSWGRSL
KYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCG
PCFNNGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSV
CRAGIQERRRECDNPAPQNGGASCPGRKVQTQAC
3D structure
PDB7nyd Structural basis of soluble membrane attack complex packaging for clearance.
ChainE
Resolution3.27 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA E N13 W14 N13 W14
BS02 CA E L83 N86 D88 D90 D96 E97 L83 N86 D88 D90 D96 E97
Gene Ontology
Molecular Function
GO:0001848 complement binding
GO:0005515 protein binding
GO:0044877 protein-containing complex binding
Biological Process
GO:0006955 immune response
GO:0006956 complement activation
GO:0006957 complement activation, alternative pathway
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nyd, PDBe:7nyd, PDBj:7nyd
PDBsum7nyd
PubMed34667172
UniProtP07357|CO8A_HUMAN Complement component C8 alpha chain (Gene Name=C8A)

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