Structure of PDB 7ngf Chain E

Receptor sequence

>7ngfE (length=776) Species: 9606 (Homo sapiens)

HLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDD
SNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEM
VEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQ
RVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFEL
SKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFR
ERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGK
YSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFY
GPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGK
IIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDH
YLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAER
YLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRK
SAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTA
MGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFAR
AFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRP
VRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYD
LAAFITEGLEVHFVEHYREIFDIAFP

3D structure

• PDB: 7ngf Catalytic cycling of human mitochondrial Lon protease.
• Chain: E
• Resolution: 5.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.53: endopeptidase La.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	E	H491 G526 V527 G528 K529 T530 Y661 I669 Y673	H319 G354 V355 G356 K357 T358 Y489 I497 Y501

Gene Ontology

Molecular Function

• GO:0004176 ATP-dependent peptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

Biological Process

• GO:0006508 proteolysis
• GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
• GO:0030163 protein catabolic process

External links

• PDB: RCSB:7ngf, PDBe:7ngf, PDBj:7ngf
• PDBsum: 7ngf
• PubMed: 35870450
• UniProt: P36776|LONM_HUMAN Lon protease homolog, mitochondrial (Gene Name=LONP1)