Structure of PDB 7n3k Chain E

Receptor sequence
>7n3kE (length=124) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
AALEVLFQGPGNNELSPVALRQMSCAAGTTQTACTDDNALAYYNTTKGGR
FVLALLSDLQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGPKVKYLY
FIKGLNNLNRGMVLGSLAATVRLQ
3D structure
PDB7n3k A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein.
ChainE
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ODN E P71 C73 R99 P82 C84 R110
Gene Ontology
Biological Process
GO:0019079 viral genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:7n3k, PDBe:7n3k, PDBj:7n3k
PDBsum7n3k
PubMed34756886
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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