Structure of PDB 7myj Chain E

Receptor sequence
>7myjE (length=303) Species: 9606 (Homo sapiens) [Search protein sequence]
SNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAP
LWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQ
DSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRIL
KFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQH
RVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYF
EGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALV
LTG
3D structure
PDB7myj Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.
ChainE
Resolution2.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP E H151 T200 I204 A205 V225 S226 H298 I312 S314 S316 D317 H128 T177 I181 A182 V202 S203 H275 I289 S291 S293 D294
BS02 AMP E R70 K170 I240 S242 D245 R269 V276 L277 V297 H298 R299 R47 K147 I217 S219 D222 R246 V253 L254 V274 H275 R276
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004691 cAMP-dependent protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008603 cAMP-dependent protein kinase regulator activity
GO:0016208 AMP binding
GO:0019887 protein kinase regulator activity
GO:0019901 protein kinase binding
GO:0043531 ADP binding
Biological Process
GO:0006110 regulation of glycolytic process
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0010628 positive regulation of gene expression
GO:0031669 cellular response to nutrient levels
GO:0045860 positive regulation of protein kinase activity
GO:0051170 import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0031588 nucleotide-activated protein kinase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7myj, PDBe:7myj, PDBj:7myj
PDBsum7myj
PubMed35552369
UniProtP54619|AAKG1_HUMAN 5'-AMP-activated protein kinase subunit gamma-1 (Gene Name=PRKAG1)

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