Structure of PDB 7mu5 Chain E

Receptor sequence
>7mu5E (length=105) Species: 9606 (Homo sapiens) [Search protein sequence]
FSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQ
WKTDGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDIN
RRRYP
3D structure
PDB7mu5 Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance
ChainE
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.12: dCTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TLI E W47 F50 W25 F28
BS02 MG E E63 E66 E95 D98 E41 E44 E70 D73
Gene Ontology
Molecular Function
GO:0047429 nucleoside triphosphate diphosphatase activity
Biological Process
GO:0009143 nucleoside triphosphate catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7mu5, PDBe:7mu5, PDBj:7mu5
PDBsum7mu5
PubMed
UniProtQ9H773|DCTP1_HUMAN dCTP pyrophosphatase 1 (Gene Name=DCTPP1)

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