Structure of PDB 7mqs Chain E

Receptor sequence
>7mqsE (length=806) Species: 9606 (Homo sapiens) [Search protein sequence]
GEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKL
IMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL
GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEE
CGDICPGTNCPATQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECL
GNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLH
HKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEK
TIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLK
IRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNL
TITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCE
NELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVVVDI
DPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSD
IIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWER
QAEDSELFELDYCLKGLKLPSRQILKELEESSFRKTFEDYLHNVVFVPRE
EHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSAR
TMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGD
EELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFY
VTDYLD
3D structure
PDB7mqs Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
ChainE
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E D535 P537 P549 G550 W551 L552 D501 P503 P515 G516 W517 L518
BS02 peptide E D707 N711 V715 P716 R717 D639 N643 V647 P648 R649
BS03 peptide E P495 F497 R498 E706 H710 F714 P476 F478 R479 E638 H642 F646
External links
PDB RCSB:7mqs, PDBe:7mqs, PDBj:7mqs
PDBsum7mqs
PubMed35289328
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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