Structure of PDB 7mqo Chain E

Receptor sequence
>7mqoE (length=602) Species: 9606 (Homo sapiens) [Search protein sequence]
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS
FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVH
LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKD
DNEECGDICPGTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEG
LCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVN
FSFCQDLHHKCKNSRCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPC
PKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANL
GLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIA
LKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYK
EAPYQNVTEFSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVK
TLVTFSDERRTYGAKSDIIYVQTDQILKELEESSFRKTFEDYLHNVVFVP
RP
3D structure
PDB7mqo Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
ChainE
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E F39 K40 R65 F39 K40 R65
BS02 peptide E D496 D707 H710 N711 V713 F714 V715 P716 R717 D488 D591 H594 N595 V597 F598 V599 P600 R601
BS03 peptide E D496 R498 E706 H710 F714 D488 R490 E590 H594 F598
External links
PDB RCSB:7mqo, PDBe:7mqo, PDBj:7mqo
PDBsum7mqo
PubMed35289328
UniProtP06213|INSR_HUMAN Insulin receptor (Gene Name=INSR)

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