Structure of PDB 7m5c Chain E

Receptor sequence
>7m5cE (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
ASEEQVAQDTEEVFRSYVFYRHQQEQEADPEMVTLPLQPSSTMGQVGRQL
AIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRV
VALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHSIARWIAQRGGWV
AALNLCN
3D structure
PDB7m5c Structural basis of BAK activation in mitochondrial apoptosis initiation.
ChainE
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E I85 R88 Y89 M96 H99 I114 S117 L118 N124 W125 G126 R127 N182 C184 I57 R60 Y61 M68 H71 I86 S89 L90 N96 W97 G98 R99 N154 C156
BS02 CU E H141 H145 H113 H117
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7m5c, PDBe:7m5c, PDBj:7m5c
PDBsum7m5c
PubMed35017502
UniProtQ16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Gene Name=BAK1)

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