Structure of PDB 7lps Chain E

Receptor sequence
>7lpsE (length=381) Species: 9606 (Homo sapiens) [Search protein sequence]
INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQT
LPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYRE
EQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSA
VQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMD
RIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAI
QRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGY
VHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTAT
KKDMSPQKFWGLTRSALLPTIPDTEDEISPD
3D structure
PDB7lps Acute pharmacological degradation of Helios destabilizes regulatory T cells.
ChainE
Resolution3.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide E N351 H353 Y355 H357 W386 V388 Q390 A395 H397 W400 N296 H298 Y300 H302 W331 V333 Q335 A340 H342 W345
BS02 ZN E C323 C326 C391 C394 C268 C271 C336 C339
BS03 RN9 E F102 N351 P352 H353 H378 W380 W386 W400 F402 F56 N296 P297 H298 H323 W325 W331 W345 F347
External links
PDB RCSB:7lps, PDBe:7lps, PDBj:7lps
PDBsum7lps
PubMed34035522
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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