Structure of PDB 7leu Chain E

Receptor sequence

>7leuE (length=423) Species: 10090 (Mus musculus) [Search protein sequence]

NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF
VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP
HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG
YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA
ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT
DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV
NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP
LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE
ALQRHENESVYKASLNLIEKYFS

3D structure

PDB

7leu Differential recognition of canonical NF-kappa B dimers by Importin alpha 3.

Chain

Resolution

2.82 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	E	S105 F138 W142 N146 S149 G150 T155 Q181 W184 N188 D192 N228 W231	S31 F64 W68 N72 S75 G76 T81 Q107 W110 N114 D118 N154 W157
BS02	peptide	E	G281 N283 R315 N319 V321 T322 G323 T328 E354 W357 N361 E396 W399	G207 N209 R241 N245 V247 T248 G249 T254 E280 W283 N287 E322 W325

External links

PDB	RCSB:7leu, PDBe:7leu, PDBj:7leu
PDBsum	7leu
PubMed	35260573
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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