Structure of PDB 7lcg Chain E

Receptor sequence
>7lcgE (length=496) Species: 64286 (Usutu virus) [Search protein sequence]
FNCLGMSNRDFLEGATWVDVVLEGDSCITIMAKDKPTIDIKMMETEATNL
AEVRSYCYLATVSDVSTVSNCPTTGEAHNPKRAEDTYVCKSGVTDRGWGN
GCGLFGKGSIDTCANFTCSLKAVGRMIQPENVKYEVGIFIHGSTSSDTHG
NYSSQLGASQAGRFTITPNSPAITVKMGDYGEISVECEPRNGLNTEAYYI
MSVGTKHFLVHREWFNDLALPWTSPASSNWRNREILLEFEEPHATKQSVV
ALGSQEGALHQALAGAVPVSFSSSVKLTSGHLKCRVKMEKLTLKGTTYGM
CTEKFSFAKNPADTGHSTVVLELQYTGSDGPCKIPISIVASLSDLTPIGR
MVTANPYVASSEANAKVLVEMEPPFGDSYIVVGRGDKQINHHWHKAGSSI
GKAFITTIKGAQRLAALGDPAWDFGSVGGIFNSVGKAVHQVFGGAFRTLF
GGMSWITQGLMGALLLWMGVNARDRSIALVMLATGGVLLFLATSVH
3D structure
PDB7lcg Structure of Usutu virus SAAR-1776 displays fusion loop asymmetry.
ChainE
Resolution2.42 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 0SM E G413 R416 A424 W425 G410 R413 A421 W422
Gene Ontology
Molecular Function
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:7lcg, PDBe:7lcg, PDBj:7lcg
PDBsum7lcg
PubMed34417300
UniProtQ5WPU5|POLG_USUV Genome polyprotein

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