Structure of PDB 7ku7 Chain E

Receptor sequence
>7ku7E (length=269) Species: 269446 (Rous sarcoma virus (strain Schmidt-Ruppin A)) [Search protein sequence]
PLREAKDLHTALHIGPRALSKACNISMQQAREVVQTCPHCNSAPALEAGV
NPRGLGPLQIWQTDFTLEPRMAPRSWLAVTVDTASSAIVVTQHGRVTSVA
VQHHWATAIAVLGRPKAIKTDNGSCFTSKSTREWLARWGIAHTTGIPGNS
QGQAMVERANRLLKDKIRVLAEGDGFMKRIPTSKQGELLAKAMYALNHFE
RGENTKTPIQKHWRPTVLTEGPPVKIRIETGEWEKGWNVLVWGRGYAAVK
NRDTDKVIWVPSRKVKPDI
3D structure
PDB7ku7 Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome.
ChainE
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna E G49 V50 N51 P52 T143 T144 G145 I146 Q151 A154 M155 R158 L162 E203 R244 Y246 G49 V50 N51 P52 T143 T144 G145 I146 Q151 A154 M155 R158 L162 E203 R244 Y246
BS02 dna E N160 R161 N160 R161
BS03 ZN E H9 H13 C37 H9 H13 C37
BS04 MG E D64 D121 D64 D121
BS05 MG E D64 E157 D64 E157
BS06 ZZX E D64 S150 E157 D64 S150 E157
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:7ku7, PDBe:7ku7, PDBj:7ku7
PDBsum7ku7
PubMed33712691
UniProtP03354|POL_RSVP Gag-Pol polyprotein (Gene Name=gag-pol)

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