Structure of PDB 7krg Chain E

Receptor sequence
>7krgE (length=265) Species: 29918 (Cladosporium herbarum) [Search protein sequence]
GQQATKHESLLDQLSLKGKVVVVTGASGPKGMGIEAARGCAEMGAAVAIT
YASRAQGAEENVKELEKTYGIKAKAYKCQVDSYESCEKLVKDVVADFGQI
DAFIANAGATADSGILDGSVEAWNHVVQVDLNGTFHCAKAVGHHFKERGT
GSLVITASMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSI
SPGYIDTGLSDFVPKETQQLWHSMIPMGRDGLAKELKGAYVYFASDASTY
TTGADLLIDGGYTTR
3D structure
PDB7krg Biochemical and clinical studies of putative allergens to assess what distinguishes them from other non-allergenic proteins in the same family.
ChainE
Resolution2.03797 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.138: mannitol 2-dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP E G27 S29 G33 M34 A54 S55 R56 Q81 V82 N108 A109 G110 T158 S160 Y175 K179 P204 G205 I207 T209 L211 G25 S27 G31 M32 A52 S53 R54 Q79 V80 N106 A107 G108 T156 S158 Y173 K177 P202 G203 I205 T207 L209
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0042803 protein homodimerization activity
GO:0050085 mannitol 2-dehydrogenase (NADP+) activity
GO:0050661 NADP binding
GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
Biological Process
GO:0019594 mannitol metabolic process
GO:0051289 protein homotetramerization

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Molecular Function
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Biological Process
External links
PDB RCSB:7krg, PDBe:7krg, PDBj:7krg
PDBsum7krg
PubMed35939227
UniProtP0C0Y5|NMTDH_DAVTA NADP-dependent mannitol dehydrogenase

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