Structure of PDB 7k3z Chain E

Receptor sequence
>7k3zE (length=562) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
GKDIIYGNECRNELLKGILTVSDVVKLTLGPRGRNVLLEKEYGSPLIIND
GVTIAKQISLKDRKKNNGVKLMQESTQISNDKAGDGTSSTALMTATITKK
GIEQVNRNHNPIPIQRGIQLASKMIIEKIKSLSTPIKTYKDILNIATIAS
NNDVHMGQIIANAYDKLGKNAAIILDDNADINDKLEFTEGYNFDRGIINP
YLLYNENKDYIEYSQVSTLITDQNIDIQSILPILEIFAKNKQPLCIIADD
FSNEVLQTLIINKLKGAIKVVPIRAPSFGDRRKDYLKDLCIVTNSKYISA
DVGLDLNNLHNQMSSFDNNYLSLLGSANTLIVKKDRTSLITKEEYKKEID
ERINVLKKEYEETTSKYDKEKLNERIAALSGGIAKILIGGNSETEQKERK
FKYEAATNAVKSAIDIGYVPGGGVTYLEIIKSNFIQEIHKKIEEDLQISS
NNDEKKYLELIGNLESEMELQKMGANIVVSSLDVITKQIADNAGVNGDNV
VKIILNSKDKYGFGYDVNTNKFVNMVEKGIIDSTNVIISVIKNSCSIASM
VLTTECMMVDHE
3D structure
PDB7k3z Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding.
ChainE
Resolution3.69 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D118 T155 S156 A474
Catalytic site (residue number reindexed from 1) D50 T87 S88 A405
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG E D153 A217 D85 A149
BS02 ATP E L97 G98 P99 D153 G154 S156 S157 N219 G490 G491 I558 D585 V586 N587 I599 D601 L29 G30 P31 D85 G86 S88 S89 N151 G421 G422 I489 D516 V517 N518 I530 D532
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0042026 protein refolding

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Molecular Function
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Biological Process
External links
PDB RCSB:7k3z, PDBe:7k3z, PDBj:7k3z
PDBsum7k3z
PubMed33723304
UniProtQ8I0V3

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