Structure of PDB 7k1h Chain E

Receptor sequence
>7k1hE (length=289) Species: 9606 (Homo sapiens) [Search protein sequence]
LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS
PKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYV
REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK
ITDFGRAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI
PASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIEF
SKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7k1h Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainE
Resolution2.602 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VNS E F723 V726 A743 I744 K745 E749 E758 I759 M766 C775 R776 L777 L788 T790 D855 F856 R858 F21 V24 A41 I42 K43 E47 E56 I57 M64 C73 R74 L75 L86 T88 D153 F154 R156
BS02 YY3 E L718 V726 A743 L792 M793 G796 C797 D800 L844 D855 L16 V24 A41 L90 M91 G94 C95 D98 L142 D153 BindingDB: IC50=2.0nM,Ki=14nM,EC50=6.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7k1h, PDBe:7k1h, PDBj:7k1h
PDBsum7k1h
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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