Structure of PDB 7jxk Chain E

Receptor sequence
>7jxkE (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY
DGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDPSPTDSNFYRALMDEEDM
3D structure
PDB7jxk Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainE
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8BS E V726 M790 Q791 L792 M793 P794 G796 C797 D800 L844 V27 M91 Q92 L93 M94 P95 G97 C98 D101 L145
BS02 JBJ E F723 A743 I744 K745 L747 T751 I759 M766 R776 L777 L788 M790 D855 F856 L858 F24 A44 I45 K46 L48 T52 I60 M67 R77 L78 L89 M91 D156 F157 L159 BindingDB: IC50=>1000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxk, PDBe:7jxk, PDBj:7jxk
PDBsum7jxk
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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