Structure of PDB 7jpr Chain E

Receptor sequence
>7jprE (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
ENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTL
ELPHVFVNCVECFTLRLLLEQILNKLNHLSSTEITCETFNDFVRLFKQVT
TAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEI
VWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINI
LLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEASERDTRKLWRNIEPH
LKKAMQTVYLREISSSQWEKLQKDDYYSKFILIAAYLASYNPARTDKRFF
LKNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLV
GHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIKYLYD
3D structure
PDB7jpr The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
ChainE
Resolution4.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E L9 T39 G42 K43 T44 Y45 K126 Y182 I190 L222 L5 T35 G38 K39 T40 Y41 K116 Y172 I180 L212
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jpr, PDBe:7jpr, PDBj:7jpr
PDBsum7jpr
PubMed32808929
UniProtO43913|ORC5_HUMAN Origin recognition complex subunit 5 (Gene Name=ORC5)

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