Structure of PDB 7jpq Chain E

Receptor sequence
>7jpqE (length=404) Species: 9606 (Homo sapiens) [Search protein sequence]
NVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLE
LPHVFVNCVECFTLRLLLEQILNKLNHLSSTEITCETFNDFVRLFKQVTT
AENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIV
WEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINIL
LGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEASERDTRKLWRNIEPHL
KKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHVELPYYSKFILI
AAYLASYNPARTDKRFFLSNHLLGPKPFPLDRLLAILYSIVDSRVAPTAN
IFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIK
YLYD
3D structure
PDB7jpq The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures.
ChainE
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E L9 T39 A40 K43 T44 Y45 Y182 I190 L222 L4 T34 A35 K38 T39 Y40 Y171 I179 L211
BS02 MG E D125 K126 D114 K115
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005694 chromosome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jpq, PDBe:7jpq, PDBj:7jpq
PDBsum7jpq
PubMed32808929
UniProtO43913|ORC5_HUMAN Origin recognition complex subunit 5 (Gene Name=ORC5)

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