Structure of PDB 7jk3 Chain E

Receptor sequence
>7jk3E (length=398) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
MEAICSSLEPLFPCREAAIETLGELIGDSSETYPSAIYLFGHSGTGKTAL
TRAFLKECGKRQNVRTAHLNAIECYTTKIMLEILLDSLAPDQGDALKVDN
MLDFVEQLRRQAATRVEDQGFLIAVDNAERLRDMDANVLPVLLRLQELTN
LNLCVILLSQLPFEKFYNKTGLSEIVCLHLAQYNKAETQRILGSDFQQVR
NQLLEQKKRLEICQEAVTEDFYNNYLNLFLSVFYKACRDVPELQLTARKC
LSTYLEPVLDGSRLWRHIAGPLRSALTQIYMRIESLELPYYAKFLLIAAF
LASHNAAKQDKRLFVKLGPKSFSIDRLLAIFYAILEEKVGLTCNLLSQIS
TLVHLNLLSFVSGEQNIMEGSARLQCTIGLEFVLQIGKVVGFNVRQYL
3D structure
PDB7jk3 Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
ChainE
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E P13 S43 G46 K47 T48 Y183 P13 S43 G46 K47 T48 Y183
BS02 MG E T48 D126 T48 D126
Gene Ontology
Molecular Function
GO:0003688 DNA replication origin binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006270 DNA replication initiation
GO:0007052 mitotic spindle organization
GO:0007076 mitotic chromosome condensation
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex

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Cellular Component
External links
PDB RCSB:7jk3, PDBe:7jk3, PDBj:7jk3
PDBsum7jk3
PubMed32848132
UniProtQ24169|ORC5_DROME Origin recognition complex subunit 5 (Gene Name=Orc5)

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