Structure of PDB 7e2h Chain E

Receptor sequence
>7e2hE (length=824) Species: 9606 (Homo sapiens) [Search protein sequence]
GSEVDWNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNS
RIRSHPQFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHT
LKLLRTCAKHYDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMT
PKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGVTTITGIE
FGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISS
LIVSYFLYRVVFHFEFFPFMNLTALIILVGIGANNAFVLCDVWNYTKFDK
PHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAG
TAILVNYVLMVTWLPAVVVLHERACQKCHKVLFAISEASRIFFEKVLPCI
VIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFER
YDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLD
SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQ
DCCCSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTI
RAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSN
LEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTI
FVTVGSLVLLGWELNVLESVTISVAVGLSVNFAVHYGVAYRLAPDPDREG
KVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISW
AFATFFFQCMCRCLGPQGTCGQIP
3D structure
PDB7e2h Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release.
ChainE
Resolution3.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 E L1029 I1118 L709 I798
BS02 Y01 E K741 M742 Y937 E938 L985 M988 K428 M429 Y617 E618 L665 M668
BS03 Y01 E Q497 L501 L563 Y1105 Q209 L213 L275 Y785
BS04 Y01 E F552 Y620 Y623 F264 Y332 Y335
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7e2h, PDBe:7e2h, PDBj:7e2h
PDBsum7e2h
PubMed34845226
UniProtQ96F81|DISP1_HUMAN Protein dispatched homolog 1 (Gene Name=DISP1)

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