Structure of PDB 7dy2 Chain E

Receptor sequence
>7dy2E (length=464) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence]
IAKMRTMIEGFDDISHGGLPIGRSTLVSGTSGTGKTLFSIQFLYNGIIEF
DEPGVFVTFEETPQDIIKNARSFGWDLAKLVDEGKLFILDASPDPGGFDL
SALIERINYAIQKYRARRVSIDSVTSVFQSSVVRRELFRLVARLKQIGAT
TVMTTERIEEYGPIARYGVEEFVSDNVVILRNVLEGERRRRTLEILKLRG
TSHMKGEYPFTITDHGINIFPLGASSNVRVSSGVVRLDEMCGGGFFKDSI
ILATGATGTGKTLLVSRFVENACANKERAILFAYEESRAQLLRNAYSWGM
DFEEMERQNLLKIVCAYPESAGLEDHLQIIKSEINDFKPARIAIDSLSAL
ARGVSNNAFRQFVIGVTGYAKQEEITGLFTNTSDQFMGAHSITDSHISTI
TDTIILLQYVEIRGEMSRAINVFKMRGSWHDKAIREFMISDKGPDIKDSF
RNFERIISGSPTRI
3D structure
PDB7dy2 Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.
ChainE
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E G49 G51 K52 T53 L54 G32 G34 K35 T36 L37
BS02 ATP E T290 G291 T292 G293 K294 T295 S330 W331 R451 I472 T257 G258 T259 G260 K261 T262 S297 W298 R418 I439
BS03 MG E E318 D378 E285 D345
BS04 ADP E K224 G227 T228 H230 K197 G200 T201 H203
BS05 ADP E K457 M458 S461 H463 K424 M425 S428 H430
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0044024 histone H2AS1 kinase activity
GO:0046872 metal ion binding
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0007623 circadian rhythm
GO:0009649 entrainment of circadian clock
GO:0016310 phosphorylation
GO:0042752 regulation of circadian rhythm
GO:0042754 negative regulation of circadian rhythm
GO:0048511 rhythmic process
GO:0070297 regulation of phosphorelay signal transduction system

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7dy2, PDBe:7dy2, PDBj:7dy2
PDBsum7dy2
PubMed35427168
UniProtQ79PF4|KAIC_SYNE7 Circadian clock oscillator protein KaiC (Gene Name=kaiC)

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