Structure of PDB 7d5l Chain E

Receptor sequence
>7d5lE (length=193) [Search protein sequence]
KGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGEVQIVST
ATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDLVGWQAP
QGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGS
SGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVESLETTMRS
3D structure
PDB7d5l Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
ChainE
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H157 D181 G237 S239
Catalytic site (residue number reindexed from 1) H69 D93 G149 S151
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E C197 C199 C245 C109 C111 C157
BS02 GXO E Q141 H157 D181 R223 L235 K236 G237 S239 F254 R255 A256 A257 D268 Q53 H69 D93 R135 L147 K148 G149 S151 F166 R167 A168 A169 D180 MOAD: ic50=4.8nM
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019062 virion attachment to host cell
GO:0019087 transformation of host cell by virus
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7d5l, PDBe:7d5l, PDBj:7d5l
PDBsum7d5l
PubMed33226226
UniProtA0A0B4WYC6

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