Structure of PDB 7ctf Chain E

Receptor sequence
>7ctfE (length=373) Species: 9606 (Homo sapiens) [Search protein sequence]
LENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKT
LELPHVFVNCVECFTLRLLLEQILNKLNHLSTEITCETFNDFVRLFKQVT
TAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEI
VWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINI
LLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEDTRKLWRNIEPHLKKA
MQTVSAHTHVELPYYSKFILIAAYLASYNPARTDKRFFNHLLGPKPFPLD
RLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCT
VSLDFIRAIARTVNFDIIKYLYD
3D structure
PDB7ctf Structural insight into the assembly and conformational activation of human origin recognition complex.
ChainE
Resolution4.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E L9 T39 A40 G42 K43 T44 Y45 L222 L6 T36 A37 G39 K40 T41 Y42 L212
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003674 molecular_function
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000785 chromatin
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
GO:0005694 chromosome
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ctf, PDBe:7ctf, PDBj:7ctf
PDBsum7ctf
PubMed33298899
UniProtO43913|ORC5_HUMAN Origin recognition complex subunit 5 (Gene Name=ORC5)

[Back to BioLiP]