Structure of PDB 7cs6 Chain E

Receptor sequence

>7cs6E (length=287) Species: 161756 (Isatis tinctoria) [Search protein sequence]

GEKTRVLVVGGTGTMGRRIVRACLAEGHETYVLQQPETRVDIEKVQLLYS
YKRLGARLIEASFSDHQSLVSAVKQVDIVVAAMSGHSILVQLKLVEAIKE
AGNIKRFLPSEFGMDPSRMDQKLEVRNAIEAAGIPHTYVVGACFAAYFAG
NLSQMGTLIPPKKKVNIYGDGNVKVVYVDEDDIAEYTAKTLDDPRTINKT
VYVRPTENVLTQMELVQIWEKLTGKELEKTNISANDFLADIAGLGHFYHI
FYEGCLTDHEVGDDEEASKLYPDVKYTRMDEYLKIFL

3D structure

PDB

7cs6 Structure-based engineering of substrate specificity for pinoresinol-lariciresinol reductases.

Chain

Resolution

2.2014 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GFR	E	G124 M125 Y169 F170 M177 G178 H276	G113 M114 Y147 F148 M155 G156 H246
BS02	NDP	E	G16 T18 G19 T20 M21 Q41 K50 F69 A88 M89 S90 S98 S121 E122 F123 K144 A164 C165 F166 Y169 F170	G10 T12 G13 T14 M15 Q35 K44 F63 A82 M83 S84 S87 S110 E111 F112 K122 A142 C143 F144 Y147 F148

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0010283	pinoresinol reductase activity
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:7cs6, PDBe:7cs6, PDBj:7cs6
PDBsum	7cs6
PubMed	33990581
UniProt	I6LRS1

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