Structure of PDB 7bre Chain E

Receptor sequence

>7breE (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]

STRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEM
VIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARF
INHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIESNKLP
CNCGAKRCRRFLN

3D structure

PDB

7bre Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.

Chain

Resolution

2.803 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	E	K2570 E2603 S2605 G2606 I2607 V2608 R2610 V2612 L2613 R2617 H2644 G2645	K20 E53 S55 G56 I57 V58 R60 V62 L63 R67 H94 G95
BS02	ZN	E	C2703 C2705 C2710	C151 C153 C158
BS03	SAH	E	I2584 H2585 G2586 R2587 Y2629 R2649 N2652 H2653 C2703 N2704	I34 H35 G36 R37 Y79 R99 N102 H103 C151 N152

External links

PDB	RCSB:7bre, PDBe:7bre, PDBj:7bre
PDBsum	7bre
PubMed	32697937
UniProt	Q9UMN6\|KMT2B_HUMAN Histone-lysine N-methyltransferase 2B (Gene Name=KMT2B)

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