Structure of PDB 7bl7 Chain E

Receptor sequence
>7bl7E (length=222) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGGG
NFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTAI
TMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIGA
DVVLMAKAVDGVFLLTAVSHREVLDRGLRVADATAFSLCMDNGMPILVFN
LLTDGNIARAVRGEKIGTLVTT
3D structure
PDB7bl7 Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
ChainE
Resolution3.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.22: UMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP E G38 G39 G77 R82 G83 D97 G100 M101 M158 L160 F163 T165 G10 G11 G49 R54 G55 D69 G72 M73 M130 L132 F135 T137
BS02 UTP E L138 L140 R141 R144 K148 L110 L112 R113 R116 K120
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0009041 UMP/dUMP kinase activity
GO:0016301 kinase activity
GO:0033862 UMP kinase activity
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006225 UDP biosynthetic process
GO:0016310 phosphorylation
GO:0044210 'de novo' CTP biosynthetic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bl7, PDBe:7bl7, PDBj:7bl7
PDBsum7bl7
PubMed35152545
UniProtP9WHK5|PYRH_MYCTU Uridylate kinase (Gene Name=pyrH)

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