Structure of PDB 7bgn Chain E

Receptor sequence
>7bgnE (length=202) Species: 3880 (Medicago truncatula) [Search protein sequence]
NAVDSLLDSVKWDNKGLAVAIAQNVDTGAILMQGFANREAVATTISSRKA
TFYSRSRSSLWTKGETSNNFINVHDVFLDCDRDSIIYLGKPDGPTCHTGA
ETCYYTPVFDNKLALTSLYALESTISQRKAEVSWTKRLLLNDKLLCSKIR
EEANELCETLENNEDKSRTASEMADVLYHAMVLLALKDVKVEEVLQVLRQ
RF
3D structure
PDB7bgn Structural and mechanistic insights into the bifunctional HISN2 enzyme catalyzing the second and third steps of histidine biosynthesis in plants.
ChainE
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.-.-.-
3.5.4.19: phosphoribosyl-AMP cyclohydrolase.
3.6.1.31: phosphoribosyl-ATP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E D125 D127 D129 D79 D81 D83
BS02 ZN E E214 E234 D237 E152 E172 D175
BS03 AMP E R183 S195 W196 Y240 R128 S133 W134 Y178
BS04 AMP E W107 K109 T112 S113 H143 W61 K63 T66 S67 H97
BS05 ZN E C142 C149 C96 C103
BS06 AMP E R263 F264 R201 F202
Gene Ontology
Molecular Function
GO:0004635 phosphoribosyl-AMP cyclohydrolase activity
GO:0004636 phosphoribosyl-ATP diphosphatase activity
Biological Process
GO:0000105 L-histidine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7bgn, PDBe:7bgn, PDBj:7bgn
PDBsum7bgn
PubMed33958623
UniProtA0A072U2X9

[Back to BioLiP]