Structure of PDB 7av7 Chain E

Receptor sequence
>7av7E (length=374) Species: 3055 (Chlamydomonas reinhardtii) [Search protein sequence]
AGKPIECKAAIAWEAKKPLEVRTVTVAPPGPGEVRVQIKATALCQTDAYT
LGGLDPEGRFPCILGHEAAGVVESVGEGVTSVKPGDHVIPCYQAYCGECK
FCKHPESNLCVSVRAFTGKGVMKSDGKPRFTVDGKPIYHFMGTSTFSEYT
VVHEQSVAKIDVNAPLDKVCLLGCGVSTGWGAVFNTAKVTAGSTVAVFGL
GAVGLAVIEAAKRAGASRIIAVDIDPTKFPTAKEFGATDCINPKDHEKPI
QQVIVEMTEWGCDYTFECIGNTAVMRAALECAHRGWGTSVIVGVAAAGQE
ISTRPFQLVTGRRWMGTAFGGYKSRVQVPDLVTDYMSGATLLDKYITHNM
KFDQINEAFELLHAGECLRCVLTF
3D structure
PDB7av7 Structural and functional insights into nitrosoglutathione reductase from Chlamydomonas reinhardtii.
ChainE
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C48 T50 Y53 H70 C178
Catalytic site (residue number reindexed from 1) C44 T46 Y49 H66 C174
Enzyme Commision number 1.1.1.284: S-(hydroxymethyl)glutathione dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN E C48 H70 E71 C178 C44 H66 E67 C174
BS02 ZN E C100 C103 C106 C114 C96 C99 C102 C110
BS03 NAD E Q49 Y96 G205 V207 D227 I228 C272 I273 V296 G297 V298 A322 F323 R373 Q45 Y92 G201 V203 D223 I224 C268 I269 V292 G293 V294 A318 F319 R369
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity
GO:0106321 S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity
GO:0106322 S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity
Biological Process
GO:0044281 small molecule metabolic process
GO:0046294 formaldehyde catabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:7av7, PDBe:7av7, PDBj:7av7
PDBsum7av7
PubMed33316743
UniProtA0A2K3D6R4

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