Structure of PDB 7alq Chain E

Receptor sequence
>7alqE (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]
PRSEEDNELNLPNLAAAYSSILSSLGENPQRQGLLKTPWRAASAMQFFTK
GYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYL
PNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVE
ATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIR
3D structure
PDB7alq Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP.
ChainE
Resolution2.205 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.16: GTP cyclohydrolase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QBQ E C141 H143 H144 V181 E183 R216 C84 H86 H87 V124 E126 R159
BS02 HBI E S228 R235 R241 S171 R178 R184
BS03 ZN E C141 H144 C212 C84 H87 C155
BS04 QBQ E L165 S166 K167 R170 L108 S109 K110 R113
BS05 HBI E D127 L157 V233 T240 E243 D70 L100 V176 T183 E186
BS06 QBQ E K93 R97 K36 R40
Gene Ontology
Molecular Function
GO:0003934 GTP cyclohydrolase I activity
Biological Process
GO:0046654 tetrahydrofolate biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7alq, PDBe:7alq, PDBj:7alq
PDBsum7alq
PubMed33387654
UniProtP30793|GCH1_HUMAN GTP cyclohydrolase 1 (Gene Name=GCH1)

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