Structure of PDB 6zww Chain E

Receptor sequence

>6zwwE (length=731) Species: 562 (Escherichia coli)

TFTALQQRLDSLMLRDRLRFSRRLHPDAQQAIFQEMAKEIDQAAGKVLLR
EAARPEITYPDNLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKIC
MELGRGIKGLIGHTQPRRLAARTVANRIAEELKTEPGGCIGYKVRFSDHV
SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFLLGYLK
ELLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPID
DTERDQLQAIFDAVDELSQESHGDILIFMSGEREIRDTADALNKLNLRHT
EILPLYARLSNSEQNRVFQSHSGRRIVLATNVAETSLTVPGIKYVIDPGT
ARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFL
SRPEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRL
LEELGAITTYKLTPLGRQLSQLPVDPRLARMVLEAQKHGCVREAMIITSA
LSIQDPRERPMDKQQASDEKHRRFHDKESDFLAFVNLWNYLGEQQKALSS
NAFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNSEPAEYREIHI
ALLTGLLSHIGMKDADKQEYTGARNARFSIFPGSGLFKKPPKWVMVAELV
ETSRLWGRIAARIDPEWVEPVAQHLIKRTYSEPHWERAQGAVMATEKVTV
YGLPIVAARKVNYSQIDPALCRELFIRHALV

3D structure

• PDB: 6zww Large-scale ratcheting in a bacterial DEAH/RHA-type RNA helicase that modulates antibiotics susceptibility.
• Chain: E
• Resolution: 3.16 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	E	R131 R132 R159 T174 G176 A180 E300 R301 A325 R326 T348 N349 V350 S354 R370 Q439 Q495 P497 V498 Q528 R533 Q600 Q642 F655 F661 R682	R117 R118 R145 T160 G162 A166 E282 R283 A307 R308 T330 N331 V332 S336 R352 Q421 Q471 P473 V474 Q504 R509 Q576 Q618 F631 F637 R658

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003724 RNA helicase activity
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity

External links

• PDB: RCSB:6zww, PDBe:6zww, PDBj:6zww
• PDBsum: 6zww
• PubMed: 34290142
• UniProt: P43329|HRPA_ECOLI ATP-dependent RNA helicase HrpA (Gene Name=hrpA)