Structure of PDB 6zi3 Chain E

Receptor sequence
>6zi3E (length=395) Species: 1890 (Streptomyces antibioticus) [Search protein sequence]
AVPAYPFSLPHALDLDPHYAELRRDEPVSRVRLPYGEGTAWLVTRMSDAR
IVLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAF
TARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICELLG
VPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPT
EDLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT
ERKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVR
AGEPCVVHFASANRDEEVFDHADELDFHRERNPHIAFGHGAHHCIGAQLG
RLELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIRGLERQIVSW
3D structure
PDB6zi3 Dissecting the Cytochrome P450 OleP Substrate Specificity: Evidence for a Preferential Substrate.
ChainE
Resolution2.08 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S180 A244 E247 T248 S249 S292 C356 I357 G358 E365 I397
Catalytic site (residue number reindexed from 1) S168 A232 E235 T236 S237 S280 C344 I345 G346 E353 I385
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM E L94 H101 R105 A244 G245 T248 L290 R298 F321 A348 F349 H354 C356 I357 G358 L82 H89 R93 A232 G233 T236 L278 R286 F309 A336 F337 H342 C344 I345 G346
BS02 DEB E F84 L94 L179 L396 F72 L82 L167 L384
BS03 RAM E E89 G92 M178 Q193 N236 S240 E77 G80 M166 Q181 N224 S228
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:6zi3, PDBe:6zi3, PDBj:6zi3
PDBsum6zi3
PubMed33036250
UniProtQ59819

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