Structure of PDB 6zhu Chain E

Receptor sequence
>6zhuE (length=993) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
AAGEIDESLYSRQLYVLGKEAMLKMQTSNVLILGLKGLGVEIAKNVVLAG
VKSMTVFDPEPVQLADLSTQFFLTEKDIGQKRGDVTRAKLAELNAYVPVN
VLDSLDDVTQLSQFQVVVATDTVSLEDKVKINEFCHSSGIRFISSETRGL
FGNTFVDLGDEFTVLDPTGEEPRTGMVSDIEPDGTVTMLDDNRHGLEDGN
FVRFSEVEGLDKLNDGTLFKVEVLGPFAFRIGSVKEYGEYKKGGIFTEVK
VPRKISFKSLKQQLSNPEFVFSDFAKFDRAAQLHLGFQALHQFAVRHNGE
LPRTMNDEDANELIKLVTDLSVQQPEVLGEGVDVNEDLIKELSYQARGDI
PGVVAFFGGLVAQEVLKACSGKFTPLKQFMYFDSLESLPDPKNFPRNEKT
TQPVNSRYDNQIAVFGLDFQKKIANSKVFLVGSGAIGCEMLKNWALLGLG
SGSDGYIVVTDNDSIEKSNLNRQFLFRPKDVGKNKSEVAAEAVCAMNPDL
KGKINAKIDKVGPETEEIFNDSFWESLDFVTNALDNVDARTYVDRRCVFY
RKPLLESGTLGTKGNTQVIIPRLTESYSSSRDPPEKSIPLCTLRSFPNKI
DHTIAWAKSLFQGYFTDSAENVNMYLTQPNFVEQTLKQSGDVKGVLESIS
DSLSSKPHNFEDCIKWARLEFEKKFNHDIKQLLFNFPKDAKTSNGEPFWS
GAKRAPTPLEFDIYNNDHFHFVVAGASLRAYNYGIKSDDSNSKPNVDEYK
SVIDHMIIPEFTPSDEIDQLVSSLPDPSTLAGFKLEPVDFEKDDDTNHHI
EFITACSNCRAQNYFIETADRQKTKFIAGRIIPAIATTTSLVTGLVNLEL
YKLIDNKTDIEQYKNGFVNLALPFFGFSEPIASPKGEYNNKKYDKIWDRF
DIKGDIKLSDLIEHFEKDEGLEITMLSYGVSLLYASFFPPKKLKERLNLP
ITQLVKLVTKKDIPAHVSTMILEICADDKEGEDVEVPFITIHL
3D structure
PDB6zhu ATP induced conformational changes facilitate E1-E2 disulfide bridging in the ubiquitin system
ChainE
Resolution3.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.2.1.45: E1 ubiquitin-activating enzyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP E R21 A444 D470 D472 N478 R481 Q482 K494 K519 V520 A542 L543 D544 N545 R12 A435 D461 D463 N469 R472 Q473 K485 K510 V511 A533 L534 D535 N536
Gene Ontology
Molecular Function
GO:0004839 ubiquitin activating enzyme activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008641 ubiquitin-like modifier activating enzyme activity
GO:0016874 ligase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 DNA damage response
GO:0016567 protein ubiquitination
GO:0036211 protein modification process
GO:0043412 macromolecule modification
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zhu, PDBe:6zhu, PDBj:6zhu
PDBsum6zhu
PubMed
UniProtP22515|UBA1_YEAST Ubiquitin-activating enzyme E1 1 (Gene Name=UBA1)

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