Structure of PDB 6zgz Chain E

Receptor sequence
>6zgzE (length=390) Species: 9606 (Homo sapiens) [Search protein sequence]
ALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLV
LPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSLEPG
TPRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTF
LQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLID
CRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVARALGA
ASLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRA
FGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCT
VTLLEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
3D structure
PDB6zgz Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia.
ChainE
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GAL E E43 H44 D46 G183 M185 D186 Y236 G346 E41 H42 D44 G181 M183 D184 Y234 G344
BS02 HFK E D83 Y109 L135 G136 S141 S142 L145 R228 D81 Y107 L133 G134 S139 S140 L143 R226
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0019402 galactitol metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
GO:0061623 glycolytic process from galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zgz, PDBe:6zgz, PDBj:6zgz
PDBsum6zgz
PubMed33724769
UniProtP51570|GALK1_HUMAN Galactokinase (Gene Name=GALK1)

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