Structure of PDB 6y32 Chain E

Receptor sequence
>6y32E (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
IINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLNKRKMIQHA
VFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRK
GWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEK
FKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQA
CEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEH
IDDFEPFKTQPFISKLLG
3D structure
PDB6y32 Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia.
ChainE
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP E G111 S112 G113 K114 T115 T116 K120 R141 G193 K249 D251 G274 G276 E277 G83 S84 G85 K86 T87 T88 K92 R113 G165 K221 D223 G246 G248 E249
BS02 GNP E Q110 R141 Q82 R113
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
Cellular Component
GO:0048500 signal recognition particle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6y32, PDBe:6y32, PDBj:6y32
PDBsum6y32
PubMed33053321
UniProtP61011|SRP54_HUMAN Signal recognition particle subunit SRP54 (Gene Name=SRP54)

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